Page 111 - Livre électronique des RFTP 2024
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In five cases, there was normalization of eosinophils within 7 to 30 days following
drug discontinuation. In one case, there were no regression of eosinophilia two
months after drug cessation.
Suspected drug was continued in the other six cases, resulting in a decrease in
eosinophil count in two cases and stabilization of eosinophil levels in three cases.
One patient experienced an exacerbation of eosinophilia, with the eosinophil count
increasing from 650/mm³ to 4960/mm³ during continuing clozapine treatment for
one month.
CONCLUSION:
Drug-induced eosinophilia tends to be misdiagnosed and underreported; there are
reports of eosinophilia especially when associated to cutaneous eruption or organ
involvement.
Drug-induced eosinophilia is a diagnosis of exclusion; other causes, most common
(allergic, parasitic,..), should be excluded. Although most cases of drug-induced
eosinophilia are asymptomatic, severe cases with hypereosinophilia syndrome
may be life threatening.
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