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P32. SERUM LACTATE DEHYDROGENASE LEVELS: A

PROGNOSTIC MARKER IN PATIENTS WITH INTERSTITIAL
LUNG DISEASE

CHARIAG MAYSSA, MOUSSA INES, TRIMECH SARRA , GUIRATI ASMA, MRASSI HANA ,
BEN HMIDA LENDA CHERIF TAREK , CHAABEN YOSSR, TLILI RAHMA, SAHNOUN IMEN ,
DOUIK ELGHARBI LEILA

UNIVERSITY OF TUNIS EL MANAR , TUNIS MEDICAL SCHOOL , PNEUMOLOGY DEPARTMENT D ,
ABDERRAHMEN MAMI HOSPITAL , ARIANA , TUNISIA

INTRODUCTION: Interstitial lung disease (ILD) contributes to significant morbidity
around the world. Predicting disease exacerbations and hospitalizations remains
challenging. Lactate dehydrogenase (LDH) is an enzyme involved in cellular
metabolism and has been implicated in various pulmonary pathologies, but its role
in ILD prognosis is not well-defined.

METHODS: A retrospective analysis of medical records from 2009 to 2024 was
conducted in pulmonary department D, Abderrahmane Mami Hospital, identifying
ILD patients with lung fibrosis on radiographic findings. Serum LDH levels among
other clinical and functional parameters were measured at the time of ILD
diagnosis, and hospitalization events were recorded during follow-up.

RESULTS: A total of 134 patients with fibrosing ILD were included, with a mean age
of 64±11 years and a gender ratio M/F=0.27. Serum LDH levels ranged from 131 to
532 U/L, with a mean of 265.2 U/L . During the study period 95.8% of patients
experienced at least one hospitalization related to ILD, with a mean hospitalization
rate of 1.57 hospitalizations in 3 years . Elevated LDH levels at baseline were
significantly associated with a higher hospitalization rate during a 3-year follow-up
( r =0.46 , p< 0.01) . This association remained robust after adjusting for
demographics, ILD subtype, and other relevant clinical factors. Statistical analysis
revealed no significant correlation between serum LDH levels and exacerbation
frequency (p =0.18). However, there was no significant correlation between serum
LDH levels and any of the pulmonary lung test parameters assessed (FEV1, p=0.37
; DLCO,p=0.42).

CONCLUSION: Our findings suggest a significant correlation between elevated
LDH levels and increased hospitalization frequency in ILD patients. LDH may serve
as a potential biomarker for disease severity and progression in this population.
Further prospective studies are warranted to elucidate the underlying mechanisms
and validate the utility of LDH monitoring in ILD management.

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